Children are especially at risk for injury because of their normal curiosity, impulsiveness and desire to master new skills. Also, children try to imitate adult behavior from an early age. It is important to know the pattern of trauma in children from developing countries as significant differences exist in socioeconomic pattern and government regulatory policies in comparison with the developed nations. A systematic review was conducted to evaluate cultural adaptability in interventional studies which were performed to prevent injuries caused by domestic accidents in children under five years old in all countries. Overall, 15 studies were entered in the analyses. 1. To assess the knowledge regarding home accidents and its prevention in children among mother of under-five children in selected urban area. 2. To assess the knowledge regarding home accidents and its prevention in children among mother of under-five children in selected rural area. 3. To compare the knowledge regarding home accidents and its prevention in children among mother of children between urban and rural area. 4. To find out significant association of knowledge score regarding home accidents and its prevention in children in selected urban area with demographic variable. 5. To find on significant association of knowledge score regarding home accidents and its prevention in children in selected rural area with demographic variable. A comparative study was conducted with 150 samples who met inclusion criteria in primary health center. the tool was used for study demographic variables and knowledge questionnaires to assess the knowledge of mother of under-five children. Non probability purposive sampling technique was used. The result that out of 150 samples of In order to compute the urban association between the level of knowledge score and demographic variables chi-square was applied and the value was observed with 5%. In order to compute the rural association between the level of knowledge score and demographic variables chi-square was applied and the value was observed with 5% significance level. the urban area mean score is 15.01 and SD is 3.08 and in rural area mean score is 12.97 and SD 3.46. The t value is 3.810 and DF is 148 and p value is <0.05The findings of the present study indicated that maximum mothers are in moderate level of knowledge regarding home accidents and its prevention in children in both urban and rural area. and also maximum mothers are in inadequate level of knowledge in rural area regarding home accidents and its prevention in children, so study conclude that there is difference in the level of knowledge regarding home accidents and its prevention in children among mother of under-five children between urban and rural area.