Background: Adverse drug reaction is now seen as one of the major reasons for mortality and morbidity in the world. Moreover, these ADRs are under-reported and underestimated. Thus, the Pharmacovigilance program has been started to reduce the risk of ADR and the safety of drugs. Depression is the most common disorder affecting people of all ages, sex, socio-economic group and religion all over the world; it may range from a very mild condition, bordering on normality, to severe (psychotic) depression. This study may reveal the common drugs which may induce ADR’s so that preventive care can be taken. Therefore the present study is planned to monitor, detect and analyze the adverse drug reactions of anti-depressant drugs in the Psychiatric Department. Aim and Objectives: Aim-To detects and analyze adverse drug reactions in patients with Depression and study patient’s compliance in tertiary care hospitals. Objectives: Primary objective- To detect the types of ADRs induced by anti-depressant drugs and also estimate its incidence rate. Secondary objective- To assess the causality & probability of ADRs, To assess the severity of patients with respect to ADRs, To study the patient’s compliance towards anti-depressant drugs. Methodology: Approval of Institutional ethics committee was taken prior to the initiation of the study. Enrolment of the patient was done as per inclusion and exclusion criteria. Only follow up patients were considered for our study to observe ADRs with the help of prescription copy. The hospital medical case record form of the patient was studied for the demographics, clinical history, clinical findings, diagnostic results and undergoing treatment and compliance. After total data collection from all patients, the ADRs were analyzed. Result: A total of 200 patients were enrolled in our study. Males were 44% while females were 56%. 49 patients between 31 to 40 years, which was mostly found in this age group. Among all ADRs seen weight gain 4%, insomnia 19%, tremors 9.5%, fatiguability 0.5%, nausea 3.5%, sedation 2%, rash 3.5%, and other 4%. Further, the causality of ADRs was observed respectively by using the WHO-causality assessment scale. In which about 54.5% cases of ADR seen to be possible, while 31.8% were unlikely and 13% of ADR were conditional ADR. Naranjo’s probability scale showed 69.6% of probable ADR while 30.3% of doubtful ADR. 82% of patients adhering to medication was measured by medication adherence rating scale while 18% were not adhering medication properly. Conclusion: Depression was seen mostly among people ranging from 31-40 years of age. Females were most affected by depression than the males. Among all the patients, Insomnia was mostly observed ADR in the patients. Other ADRs seen in patients were tremors, fatiguability, rash, weight gain, etc. Only possible and unlikely ADRs were found. Most of the patients were adhering to medication.