This paper is an effort to find out about both cities, Cairo in the Arab world and Istanbul's historical heritage, literature, and cultural horizons. Cairo and Istanbul are as ancient as Arab and Turkish ties are deeply rooted, perhaps even more so. In the Ottoman Empire, the Arabic language received significant attention from the Turks in the past and before the declaration of the Turkish Republic. In terms of the number of old Masjids and other ancient Islamic architectural sites, Cairo and Istanbul have a common history. During the reign of the Ottoman Empire, almost all of the historical sites, whether in Cairo or Istanbul, were supervised by the same sultans. However, culturally and historically, each city has its own characteristics. Though Cairo is Arab and Istanbul is not, both have many things in common in terms of civilization, culture, and history. This paper sheds light on the key issues discussed in both cities by Arab and Turkish literature.