Drug Utilization Pattern is defined by WHO in 1977 as "the marketing, distribution, prescription and the use of drugs in a society, with special emphasis on the resulting medical, social and economic consequences”. The aim is to evaluate the Drug Utilization Pattern of cephalosporins in respiratory tract infections. Methods: In a prospective observational study performed over a 6 months period (2017-2018), hospitalized adult patients who received cephalosporins for respiratory tract infections were selected. The collected data included demographic details, information regarding a cough, phlegm, periods of a cough and phlegm, breathlessness, wheezing, chest illness, past illness, tobacco, and smoking. Over the study period, 185 patients were evaluated. Lower Respiratory Tract infected patients (130) 70.3% were more than Upper Respiratory Tract (55) 29.7%. Majority patients came with a complaint of breathing (113) 61.1% difficulty following by acute exacerbation of COPD (39) 21.1%. First, second and third generation cephalosporins were prescribed. Out of which, the third generation were mostly prescribed than the other two; ceftriaxone 51.4% and cefixime 22.2 %.Around (83) 44.9% patients were having co-morbid conditions, diabetes followed by hypertension.