The rate of Emergence of antibiotic-resistant bacteria has become exponential in recent times due to the irrational exploitation of antibiotics. If this trend continues, the world and human civilization as we know it would be pushed back to the dark pre-antibiotic age. Bacteriophages could hold the key to abate the antibiotic crisis. Bacteriophages are the viruses that specifically infect and kill prokaryotic bacteria sparing human eukaryotic cells and also has a limited effect on the human microbiome this dogma makes them suitable candidates to replace antibiotics in the near future. Bacteriophages, by using a novel mechanism than the conventional antibiotics would empower us to treat drug-resistant bacterial infections, they can also be used along with antibiotics to give a maximum effect to terminate bacterial infections. Phage therapy was already in use before the discovery of antibiotics however, discovery and development of antibiotics dampened their progress in modern therapeutics. In the current scenario, it seems vital to reinvent and reestablish phage therapy and employ them to treat infections by superbugs. Plenty of groundbreaking research has been done in the past few years regarding the usage of phages in modern therapeutics. Bacteriophages, if studied properly, has the potential to supplement or even substitute antibiotics. This review will provide information on the lytic mechanism of phages, summaries of successful research done by using phage therapy against bacteria in the animal model, and current human trials along with synergism between antibiotics and phages. Some of the key aspects of synthetic or bioengineered phages and their uses are also incorporated. Finally, a discussion on solutions for carving a path for the successful employment of phage therapy in the future is inserted.