Siddha System is one of the oldest system practiced in South India especially in Tamil Nadu. Now a days Traditional system are highly encouraged by the public for treating diseases. But the major claim against the system is toxic nature of minerals and metals are used by the traditional medicines. Siddhar’s who are the inventors of Siddha medicines not only provide the medicinal preparation for treating diseases. They also mentioned the detoxification methodologies for purifying the ingredients of the medicinal preparations not only the metals and minerals even plants they mention it. Purification and Preparation procedure will done as per the literature evidence is the only opportunity to break the claim that higher order medicines are toxic nature. And acceptance of Siddha system of medicine around the world is possible. This article is a finger print review study for availability of many purification methodogies in Siddha system of medicine.