Oral route is considered as the most common and preferred technique for drug administration because it is considered as the easiest and simplest method. The route provides simplicity of drug administration in a handy way and individuals tend to be more knowledgeable about this particular route. The latest developments in Novel Drug Delivery System (NDDS) seeks for improving effectiveness and molecules security that were used previously by preparing a suitable dosage forms for administration. Now a days the problems such as dysphagia are faced by the conventional dosage forms like capsules and tablets, which results in ineffective therapy because of high incidence of non-compliance. Mouth dissolving tablets (MDTs) were developed to prevent above issues in conventional dosage forms. These MDTs have easy administration, dose uniformity, and good hardness as well as are the first preference for the travelling, geriatric, and pediatric patients. This paper provides a review for MDT because of its wide significance, as well as such drug delivery system may help for better compliance of patient along with ultimate clinical output.