From ancient times, Ayurveda has its own relevance and is known for its mystical effect. In Hindu mythology, during Satyug when Lord Hanuman went all the way to Himalayas to find a magical herb which had the power to cure any malady known as Sanjeevani booti (Selaginella bryopteris) to save the life of Lakshmana. Ayurveda marks its presence even today and has achieved different level of excellence. As it is said that Sanjeevani glowed in dark, so did the Ayurveda or science of life. It is an ancient system of natural and holistic medicine which broadly utilizes the secondary metabolites released from certain plants. Like in Ashwagandha various secondary metabolites are present like Withaferin A which has anti-cancer properties. It also has great effect on anxiety, diabetes, high cholesterol, arthritis, tumours, tuberculosis and a number of other diseases. Formation of memories can also be improved using Ashwagandha, so it is used to treat Alzheimer’s disease. In this presentation we will discuss the process for obtaining the secondary metabolites from various medicinally important plants. For obtaining these vital secondary metabolites a suitable extraction technique is also mandatory. Extraction is an important step for the isolation of phytochemicals from plant materials. A specific technique and optimization of various parameters can be utilized for the isolation of a peculiar type of secondary metabolites. In this paper we have discussed some of the main ingredients found in some of the most powerful medicinal plants which includes Withaferin A extracted from Withania somnifera, digoxin from Digitalis purpurea and Morphine from Papaver somniferum. We have also discussed some of the most suitable processes which are used for their extraction depending on their properties. Like in Withaferin A, we used solvent extraction and cell suspension culture for its isolation. We have also discussed their role in the treatment of present diseases. A newer approach is also introduced of derivatization of active ingredient which leads to its enhancing effect which can be highly useful to produce or synthesize more effective drugs.