Cosmetic industry which has gained much interest when it comes to daily based products involving skin care and many essentials enhancing and beautifying an individual. Focusing on skin care products bar soaps, liquid or gels of body wash, cleansers etc. having much demand in cosmetic sector past decade. Taking into the account preparation of body washes and cleansers using syndets i.e. synthetic surfactants leads to skin related issues like dryness, itching, after wash tightness, stratum corneum layer damage, dermatitis etc. Replacement of synthetic surfactants with mild synthetic and/or natural ones is having much wide scope for industries who develops the natural surfactants and make sure that replacement of same will lead to better application while reducing the skin related issues. During 1950’s synthetic surfactants/ detergents in form of bars are introduced. Since then body soaps and cleansers are under research which can be efficacious still less harsh causing minimal damage to the skin barrier. Cleansers including mild synthetic surfactants and/or emollients for moisturization that cause minimal barrier perturbation are ideal for these patients. A brief review of four clinical trials that evaluated the efficacy and compatibility of either mild syndet bars or cleansers in patients with atopic dermatitis, acne, and rosacea was taken. Much research and review was done on natural, mild, and biosurfactants. Biosurfactants are consider as safe and produced using nonpathogenic yeasts, bacteria, and fungi leading to production of diverse groups of biosurfactants shows antimicrobial, antifungal like properties which makes them more applicable in many daily products. Along with this addition of emollients like oils, butters, derivatives of alkanes and alcohols lead to form preparations which are having moisturizing effects and properties of surfactants which helps keeping skin intact and moisturized.