In the present scenario, one of the biggest threats to computers and mobile devices is malware. There are two approaches to detect and prevent malware infections: Signaturebased and Behavior-based approach. The Signature-based approach is more widely used, but this outlook can only be used to detect existing and old malwares and it does not allow understanding future threats and militating against these threats. The Behaviorbased approach uses a dynamic analysis method to understand and classify malwares. However, it is still not as favored as its counterpart due to its limiting behavior. In this paper, we study both Signature-based and Behavior-based approaches to determine which the favorable approach to malware detection is.