Understanding factors influencing the Quality of Life (QoL) of people has been a subject of growing interest, as measurement of QoL includes subjective dimensions of general well-being of individuals. The present study is aimed at assessing the QoL as perceived by Indian adults and arriving at a cutoff for categorizing QoL. A cross-sectional survey was conducted on a stratified sample of 2762 adults in 8 cities representing 4 geographical zones of India - North, South, East and West. WHOQoL-BREF was self-administered to measure QoL while a structured questionnaire and an app-based 24-hr diet recall were used to assess perceptions and practices about health and nutrition that affect QoL. The QoL scores were computed in accordance with WHO manual and cutoff value was arrived based on percentage mean score to categorize respondents as having poor and good QoL. Descriptive statistics were reported as mean, standard deviation, percentage for the scores and other variables, while a two-sample t-test was performed to compare the QoL scores for independent variables. The QoL percentage mean score of 68.5 for the sample population was obtained which was considered as a cutoff for categorizing QoL. It was observed that nearly half of the respondents (46.2%) had poor QoL. Men had a better QoL score than women while older adults had lower scores than younger adults (P<0.01). Being employed and higher socio-economic status positively impacted the QoL. From the 8 cities, Mumbai had the highest percentage of respondents with good QoL. Almost all respondents agreed that nutrition plays an important role in having good QoL, however, protein and micronutrient intake showed a huge gap. In conclusion, QoL assessment could be an important tool towards holistic approach to health and can assist individuals and healthcare professionals to take impactful steps towards improving QoL of the population.