Background and objectives Corticosteroid therapy are widely used therapy in every health setting to treat various disease conditions. The therapy has a lot of the adverse effects which can be prevented and monitored and also managed by the skill full nurse having competent knowledge and practice in the use of corticosteroid therapy. Many patients who receive corticosteroid therapy go home the same day or the other day, but nursing instruction is very necessary for improving the patient knowledge regarding the adverse effects of the therapy so to prevent the side effects of the therapy. Thus the nurses' knowledge and practice must be improved for the betterment of the care given to the patients. The objectives of this study were: 1. To assess the knowledge and practice score of subjects regarding the role of a nurse in corticosteroid therapy. 2. To administer information booklet 3. To determine the effectiveness of information booklet regarding the role of a nurse in corticosteroid therapy in terms of gain in knowledge and practice scores of subjects. 4. To find the association of pre-test scores of knowledge and practice of subjects with their selected socio-demographic variables. Method A quasi-experimental study with one group pre & post-test design was used to assess the effectiveness of Information Booklet on knowledge and practice regarding Role of Nurse in Corticosteroid Therapy. Simple random sampling technique (Probability) was used to collect data from 50subjects working at the selected health facility, Bengaluru. The data was collected and interpreted to assess the effectiveness of Information Booklet on knowledge and practice regarding Role of Nurse in Corticosteroid Therapy. Results The findings of the study with regard to pre-test knowledge assessment revealed that the mean percentage was 35.55% with a standard deviation of 7.64. In the pre-test knowledge level, 88% had inadequate knowledge. In the post-test, a significant increase in knowledge was found. However, in post-test, the mean percentage of knowledge was 86.55% with 6.46 standard deviation. In the post-test knowledge level, 94% had adequate knowledge. In pre-test knowledge of practice level, the mean percentage is 31.9% with a standard deviation of 4.56. There is a significant increase in practice level in post test with a mean percentage score of 80.7% with standard deviation 4.12 by the subjects. Interpretation and Conclusion The study proved that subjects had inadequate knowledge and knowledge of practice on Role of nurse in corticosteroid therapy. The finding of the study showed that the information booklet was highly effective in increasing knowledge and knowledge of practice on Role of nurse in corticosteroid therapy. In the post-test, a significant association was found with most of the variables of the subjects. The overall knowledge means a score of the pre-test was 35.55% with a standard deviation of 7.64 and an overall post-test score of knowledge was 86.55% with 6.46 standard deviation. The overall knowledge of practice means a score of the pre-test was 31.9% with standard deviation 4.56 and post test practice score was 80.7% with standard deviation 4.12. The ’t’ value of the knowledge is 16.32 %. It shows that there is a significant increase in knowledge after the administration of Information Booklet (IB). The enhancement in the subject’s knowledge is by 51 %. The statistical paired 't' test indicate that enhancement in the mean knowledge scores was found to be significant with “t” value 12.29 level for all aspects under study. The enhancement in the respondent’s practice is by 70.7%. The statistical paired 't' test indicate that enhancement in the mean knowledge scores was found to be significant with 14.21 level for all aspects under study.