Drug addiction/abuse is a social problem, not in India alone, but the entire world. The use of drugs has its own culture and history, which varies from country to country. The problem of drug abuse is growing at an explosive rate and in just a little, over a decade it has spread its malevolent tentacles to almost every part of the globe surmounting almost all barriers of race, caste, creed, religion, sex, educational status, economic strata, etc. Drug addiction among adolescents has become a global challenge and also an important public health concern and for the past two decades, there has been a dramatic increase in the demand for interventions to address the substance abuse problem. This demand has led to the development of multiple primary, secondary and tertiary substance abuse prevention programs. Material and Method: In this study quasi-experimental two-group pre-test - the post-test design was adopted. The study sample considers the 60 students’ high school regarding drug addiction in selected High schools in selected rural areas. Its shows that the difference between pre-test and post-test overall knowledge score was 28.26%. So the results of the study showed the difference between the pre-test and post-test knowledge scores of the high school students regarding drug addiction were statistically significant and the difference is due to the administration of structured teaching programs to high school students regarding drug addiction. The post-test analysis revealed there is significant association was found with age, monthly income of the family, year of high school study, and source of information regarding drug addiction at p < 0.05, and no association could be found with other demographic variables of high school students. Conclusion: The majority of students awarded with the substance abuse side effect, Treatment, Coping with addiction by structured teaching Programme. The rise in drug use by young adolescents requires special attention from all the adults (and institutions) who work with the young college-going population.