Middle adulthood, typically spanning from the ages of 40 to 65, is a significant phase in an individual's life characterized by various physical, emotional, and psychological changes. Among these changes, the evolution of one's sexual identity and experience remains a critical aspect of overall well-being. Nurses, as frontline healthcare providers, are ideally positioned to address these issues through client-centered interventions. This research study aims to investigate the efficacy of nurse-driven client-centered interventions in addressing sexuality-related issues among middle-aged adults. It will explore the impact of such interventions on sexual health outcomes, emotional well-being, and overall quality of life in this population. Methods: The research approach adopted for the study was a true experimental design. The selection of subjects was done by Simple random sampling technique method and the sample consisted of 10 middle adulthoods residing in Achankuttapatty, Salem, Tamil Nadu. The data was collected by administering Multi-dimensional Sexuality Questionnaire (MSCQ) questionnaires The validity and reliability of the tool were obtained. The collected data were analyzed by using descriptive and inferential statistics in terms of Frequency, Percentage distribution chi-square test, and independent ‘t-test. Results: In the experimental group most (75%) of them were moderate satisfaction whereas in the control group most (60%) of them were severe satisfaction. The overall mean percentage in the experimental group was 83% whereas in the control group, it was 66%, revealing a difference of 17%. The paired test value in the experimental group was 19.1 whereas in the control group, it was. The unpaired test value was 8.4, which shows that there is a highly significant difference between the experimental group and the control group post post-test scores of sexuality in middle adulthood. Conclusion: From the findings it can be concluded that hallmark Vs resilience training and behavioral intervention were effective in improving the functions of sexuality in middle adulthood.