Biofouling is the undesirable accumulation of microorganisms, plants, algae and animals on submerged structures especially ship hulls. Biofouling also occurs on the surface of living marine organisms. It is also found on membrane systems such as membrane bioreactors and reverse osmosis spiral wound membranes.The application of TBT and other heavy metal-based antifoulants has created another environmental problem.This review article summarizes the adhesion mechanisms of biofouling organism, type of biofoulers and technique to prevent artificial surfaces from marine fouling organisms. The antifouling methods based on traditional chemical methods, biological methods, and physical methods are discussed. The chemical methods include such as tributyltin self-polishing copolymer base coatings, it having good performance among the other coating but this coatings cause’s serious environmental problem. Hence, we focus on other antifouling coatings include coatings with base on copper acrylate, TBT free self-polishing co-polymer coating,Non-toxic antifouling Coating mostly silicon base chemistry,Biological antifouling methods including Enzymes that degrade adhesive used for settlement, Enzyme that disrupt the biofilm matrix, Enzyme that generate deterrents and biocides, Physical methods. In this review paper, most of the focused non-toxic antifouling technologies are discussed. It is concluded that Low Surface Energy Anti-fouling Coatings, Modified Organic Silicone Anti-fouling Coatings, Modified Organic Fluorine Anti-fouling Coatings, Fluorine Silicone Resin Anti-fouling Coatings because of their excellent effectiveness and low toxicity.