In the field of inorganic separation, the incentive to explore the use of non-aqueous or mixed solvent has been enhanced selectivity’s, discovered quite early in such media for Zeolites [1] and ion exchange resins [2]. The partial substitution of an aqueous solution by organic solvent produces a number of changes in an exchange system. Such as a change in the solution structure due to the interaction between water and the organic solvent, change in the hydration and salvation of the electrolyte, change in the solvent composition in the resin phase, change in the activity coefficients of the electrolyte in the solution phase as well as in the resin phase, change in the complexation of the metal ion and change in the extent of invasion by an electrolyte. All these changes are mutually dependent and affect the distribution of the metal ion. The solution composition in the resin phase often differs very much from that in the outer solution and the difference becomes greater with less polar organic solvents. Such behavior the selective swelling is mainly attributed to the hydration and salvation proportion of the functional resin group, namely the fixed ion and counterion. The difference in the composition of the resultant solution in the two phases enhances the invasion of electrolyte so that it is larger than in the pure aqueous solution. The electrolyte plays a significant role in the ion exchange equilibrium with aqueous solutions. This effect is expected to be even more important in the adsorption equilibriums of metal ions from mixed aqueous organic solvents. Adsorption equilibrium depends on the properties of the organic solvent reactions with resin and electrolytes which determine the equilibrium.