There are many diseases which commonly occurs in all age groups, one of which is Pandu Vyadhi. In all Ayurveda samhita Pandu Vyadhi is described as a condition in which skin becomes pallor or yellowish white in colour. This disease comes under Raktdhatu Kshaya & Rasvaha Strotas dushti. It is correlated with anaemia, evaluation of its severity is done by haemoglobin percentage. Every disease can be diagnosed by two ways, one by clinical presentation & another way by pathological investigation. Pandu Vyadhi has Vishistha lakshanatmak presentation by this, primary diagnosis can be done & by haemoglobin percentage diagnosis can be confirmed on opd basis. Proper diagnosis helps in proper drug management. Aacharya Charak explained Mandur Bhasm &Punarnavadi Mandur as a drug management for Pandu Vyadhi. Aacharya Vagbhata suggests use of Aarogyavardhini vati. In this paper a single case study is presented. A male patient is diagnosed by clinical presentation &signs which further confirmed by Hb%evaluation which was 5.9gm%.Drug management is given in combination, after one month of follow up there is subjective improvement in patient & Hb%was 9.9 gm %is noticed. Which enlightens the importance of diagnosis & effect of drug management given.