The real world Parkinson’s Disease(PD) is a chronic progressive neurological disease that affects a small area of nerve cells called neurons in the area of the brain called the substantia nigra. Medical Expert System technique is a solution of this problem. This paper summarizes regarding the classification of Parkinson’s disease by using adaptive neuro fuzzy inference engines. The learning focuses on diagnosis of P.D. by using adaptive neuro fuzzy inference system(ANFIS). The outcome obtained by fuzzy inference system is evaluated. MATLAB toolbox is designed for the simulation of the model. This also confirms that adaptive neuro is better option in which we use the symptoms of the patient which is suffering from Parkinson’s Disease and get a result.