The main objective of this project is to protect the building by designing it as earthquake resistance structure. “Base Isolation’’ is one of the most widely accepted seismic protection system used in building a structure in an earthquake-prone area. There are many types of base isolation systems but Lead rubber Bearing (LRB) is used as base isolation system in this project, LRB is most widely used as isolation system for a building. So, in this paper, we analyzed the structure with base isolation by using E-Tab software & by adopting a Time History Analysis Method. Base Isolation system for the building is introduced to decouple the building structure from potentially damaging effect by earthquake motion and to make a comparison between the isolated base & fixed base building.