Ayurveda is a science which is having its own diagnostic methods and treatment based on it. Ayurvedic classical texts elaborate treatment of Vandhytva (infertility), in almost all important Samhitas. In present scientific research, many causes of infertility are explored because of the vast availability of diagnostic tools. In the period when Samhita's were written the diagnostic methods are very different, so when acharya cite the treatment, it was quoted that the treatment is useful in infertility, as a general term. It is need of an hour to analyze this ancient treasure of treatment in terms of modern scientific knowledge. This effort will help a clinician to find the absolute indication of the infertility treatment. In this analytical study the infertility treatment mentioned in Yogratnakar, (one of the classical texts) is critically evaluated to find out the absolute indication. The chapter from Yogaratnakar namely “Yonivyapada Roganam Chikitsa, Vandhyarog Chikitsa” is critically analyzed. It is observed that the formulations which are evaluated are having estrogenic action, potent aphrodisiac, endocrine stimulants, so they are useful in unovulation, tubal block, luteal phase defect, disorders of the endocrine system also in defective spermatogenesis.