Since the 1940s, nuclear fusion has been viewed as a potential energy source, with the first patent for a fusion reactor being filed in 1946. Since then, substantial progress has been made with an ignition breakthrough happening at the Lawrence-Livermore National Laboratory (LLNL). The viability of using nuclear fusion to assist in the transition away from fossil fuels is becoming an increasingly appealing prospect; however, there are multiple questions on how such a project will work, including the choice of the most appropriate fuel mixture to use and identifying factors influencing selection. In this paper, we compare the three popular fuel mixtures: deuterium-tritium, deuterium-helion, and proton-boron on the basis of the chances each has of releasing the maximum amount of energy while taking in the lowest amount of energy possible, their environmental impacts, and commercial viability, and recommend deuterium-tritium mixture based on the aforementioned factors.