Several studies show that dental procedures especially in case of gingivitis, peri-apical lesions and periodontitis with inflamed periodontal tissues or infected pocket epithelium surrounding the teeth may be a cause of bacterial invasion through the bloodstream and resulting in Infective endocarditis which is a severe disease that may affect the heart valves or the endocardium. The most common bacteria responsible for bacterial endocarditis are alpha-hemolytic streptococci like Streptococcus viridians but oral pathogens like Eikenella corrodens, Aggregatibacter actinomycetemcomitans, Capnocytophaga, and Lactobacillus species can cause bacterial endocarditis. In this review, we searched the United States National Library of Medicine at the National Institutes of Health (PubMed) to make out all articles that included the terms endocarditic, prophylaxis, oral or dental in the title. Several published sources of information relating to dental procedures, bacteremia, and infective endocarditis were reviewed. This review is focused on the patients that need prophylactic antibiotics and the recommended antibiotics for adults and children for dental procedures in which the prophylaxis is necessary. Antibiotic prophylaxis is indicated for patients with prosthetic cardiac valve, history of infective endocarditis, distinct Congenital Heart Diseases (CHD) and Cardiac transplant recipients with cardiac valvular disease. The most important pathogen responsible for endocarditis during dental procedures is S viridans (alpha-hemolytic streptococci). Antibiotic regimens for endocarditis prophylaxis are used against S viricians, and the recommended standard prophylactic regimen is a single dose of oral amoxicillin. For patients with high cardiac risk, antibiotic prophylaxis is recommended for all dental procedures like manipulation of gingival tissue or the periapical area of teeth or perforation of the oral mucosa.