The present work is aimed to screen and test the anti-microbial properties of active principles, extracted from a few of the plants commonly grown in various parts of Koppal locality. Modern scientific medicine has concentrated to a large extent on curative or system regulating medicines, many other medicines that are synthetics also duplicated the plant products chemically, but there is nothing as good and as pure as nature. Some of the medicinal plants are believed to cure practically every human ailment from head to toe; no doubt many mineral and animal products are used as medicines. But it is the plants and their products that contribute to a greater extent in the preparation of medicine (Hill, 1979). Well, the best of these herbal medicines have in fact been incorporated in modern medicines. There is much to explore from the herbs of medicinal value using our knowledge that has been perpetuated from generations. In the present study, the ethonolic extract of E.officinalis indicated the strong inhibition against S.typhi, E.coli, and P.aeruginosa. Indicating the antibacterial activity against the pathogenic organisms.