The present study was designed to investigate the antinociceptive activity of two species of Cadaba leaf extract using central and peripheral pain model viz., tail flick, tail immersion, hot plate method and acetic acid-induced writhing method (thermal and chemical stimuli). Alcohol and aqueous extract of Cadaba fruticosa and Cadaba trifoliata were administered orally at doses of 100 and 300 mg/kg to Swiss albino mice and Wistar rats. It was evident that 100mg and 300mg of aqueous and alcohol extract of C.trifoliata exhibited statistically significant antinociceptive activity against thermal stimuli. The effect was more profound in the heat-induced pain model than chemical-induced. This finding substantiates the traditional claim mentioned in the classical texts.