Continuous Ambulatory Peritoneal Dialysis (CAPD) was identified as the best alternative treatment for developing countries like Sri Lanka having an increasing number of CKD and CKDu patients. Caregivers of CAPD patients play an important role in this treatment regime. However, the assessment of knowledge of caregivers of CAPD patients was not conducted systematically. This study aims to evaluate the knowledge of caregivers and improves the knowledge. The study was conducted in three stages, i.e. pre-interventional, interventional and post-interventional. The results obtained by the pre-intervention were analyzed and gaps were identified under each key area. Strategies were identified to achieve better patient safety practices. Further, the training/ workshop plan was conducted to improve the knowledge of caregivers at Divisional Hospital Girandurukotte. To check the effectiveness of the intervention statistically, a paired t-test was used. Correct answer count was obtained for each caregiver before and after data sets separately and marks were assigned for knowledge of each caregiver. Then averages were calculated for both datasets. Finally, using the paired t-test, before and after average marks were compared. The percentage of caregivers who gave correct answers increased after the intervention. Paired T-test results illustrate that there is a significant difference between before and after intervention Since the p-value is less than the 5% significance level, it can be concluded that after the intervention average marks of caregivers increased. Therefore, this intervention positively impacts the caregiver’s awareness. Therefore, continuous educational programs for all patients and caregivers who receiving CAPD treatment are recommended to improve knowledge about treatment.