Medicinal plants are those plants which are used in various traditional systems of medicines throughout the world that provide people with medicines - to prevent disease, maintain health or cure ailments. These medicinal plants consider as a rich resource of ingredients which contains substances that can be used for therapeutic purposes or which are precursors for the synthesis of useful drugs. Chlorophytum laxum R.Br. (commonly called as “Neeruvatti”) belongs to the family Liliaceae is one of the important medicinal plant used by Kani tribes. The present study aims to scientifically evaluate the anti-inflammatory potential of Chlorophytum laxum R. Br. In this study, Carrageenan and Formalin induced hind paw oedema models were used for in vivo anti-inflammatory study and HRBC membrane stabilization assay was used as in vitro anti-inflammatory study. The extract were administered at different doses and the maximum percentage inhibition of paw oedema in the right hind limb was shown by 450 mg/kg in both in vivo methods. The extract at a higher concentration protects significantly the hypotonicity induced hemolysis of RBC by in vitro anti-inflammatory analysis. These reveal the anti-inflammatory potential of Chlorophytum laxum. Hence the present study substantiates the medicinal properties of Chlorophytum laxum which is having antiinflammatory potential that have to be used commercially for the drug preparation.