Background: The partner and localizer of breast cancer 2 (PALB2) has an essential role in BRCA2 mediated DNA double-strand break repair by serving as a bridging molecule and acting as the physical and functional link between BRCA1& 2 proteins. Truncating mutations in the PALB2 gene are rare but are thought to be associated with increased risk of developing breast and /or ovarian cancer in different populations. The present study was designed to investigate the variants of PALB2 and their association with OC. Material & Methods: A total of 150 histopathologically confirmed ovarian cancer patients and 250 healthy age-matched controls were collected. Three SNPs c.2794 G/A( rs45624036), c.1010 T/C(rs45494092), and c.1676A/G(rs152451) of PALB2 gene were selected and genotyped by ARMS-PCR followed by agarose gel electrophoresis. Appropriate statistical tests were applied to test for the significance of the results. Results: A significant association of G/A (rs45624036) in inheritance models was observed & at the allelic level, the A allele conferred four-fold increased risk compared to G allele. Regarding T/C (rs45494092) polymorphism all the models revealed an association with OC and C allele showing eight-fold increased risk. With respect to A/G(rs152451) polymorphism, the protective role was observed in tested inheritance models in OC patients. The Haplo analysis for the combination of all the three variants revealed increased risk with A-T-A and G-C- G haplotypes.(OR=4.50 ;95%CI 1.85-10.94;p=0.001,OR=26.36 ;95%CI 2.33 -297.91;p= 0.0085), whereas other haplotypes conferred a protective role in OC. Conclusions: The present study suggests an essential role of PALB2 in the etiology of ovarian cancer.