Arthritis is inflammation or degeneration of joints. There are more than 100 different types of arthritis most common types of inflammatory arthritis include Juvenile rheumatoid arthritis (in children’s), Rheumatoid Arthritis (RA) (in adults), Psoriatic arthritis, gout, osteoarthritis, gonococcal Arthritis, etc. Rheumatoid Arthritis (RA) is an autoimmune disease. It is also a systemic disease which means it affects the whole body. People with Rheumatoid Arthritis (RA) have a higher risk of some other conditions such as heart disease, obesity, depression, anxiety, high blood pressure, diabetes, etc. No one knows the definite cause of this disease, but there is researcher’s evidence that genetics, environmental and stochastic factors are involved. There are various drugs therapies and treatments are available to suppress Rheumatoid Arthritis (RA) and there is a need for an alternative approach to avoid unnecessary side effects and high cost. Therefore, phytochemicals are used which include anti-inflammatory properties. Thus, the present study is aimed for finding phytochemical which is Stigmasterol showing higher binding affinity towards the target receptors those are 4JJ7, 6E28, 5GJH, 4FKL, 4EK4, 3CZF, 5NI9, 4RI5, 5BXU and 5N86 using molecular docking approach to find out potential drug molecule against protein causes inflammation. Tools used for molecular docking were GROMACS 5.1.1 for protein optimization, AutoDock 4.2.6 software for docking & Discovery Studio for visualization. Stigmasterol was ranked top among various docking conformations showing highest binding affinity with the target. Therefore it could be an alternative treatment method for rheumatic disorders. Plants like Glycine max (soybean), Physostigma venenosum (calabar bean), Brassica napus (rapeseed) comprise of this phytochemical. Further studies can confirm the usage of this phytochemical and plants for suppressing inflammation via inflammation