Osseo-integrated dental implants have been widely used for the rehabilitation of tooth loss. Although dental implants are considered an available treatment in the paradigm shift from traditional dental therapies, such as fixed dental bridges and removable dentures, the fundamental problems must be overcome prior to their clinical use in young patients who are still undergoing jawbone growth. A bio-engineered functional bio-hybrid implant that is combined with adult-derived periodontal tissue and attached with bone tissue can act as a substitute for cementum. This bio-hybrid implant was successfully engrafted and it restored physiological function, including bone remodelling, regeneration and appropriate responsiveness to noxious stimuli. Thus, this article reviews the functional bio-hybrid implant’s potential for clinical use as a next-generation dental implant using adult-derived tissues.