The Present studies were carried to evaluate the antimicrobial activity against soil microbes which causes corrosion on buried metal in acidic mediated soil by agar well diffusion using aqueous and ethanol extract of Neem leaves. These plants were subjected to solvent extraction with water and ethanol on increasing the polarity to identify and isolate the antimicrobial active materials. Crude aqueous extract of Neem has significantly inhibited the important microbes which causing corrosion such as S. Aureus, Streptococcus, B. Subtitles, Lactobacillus, Proteus, Corynebacterium, Pseudomonas, A.niger, Mucor and Desulphovibro sp. Results of the present studies investigation suggest that Neem is important effective plant for further work on isolating and characterizing of antimicrobial active materials.