Preclinical testing using animal models has been crucial in drug development process, but issues of ethical factors and species variances still remain. However, human derived in vitro cell-based assays are being actively practised to study drug’s pharmacokinetics and pharmacodynamics. Although, current in vitro cell assays give the drug's potential therapeutic benefits, it is only specific to a tissue but not to an entire body to accurately predict the compound’s efficacy, toxicity and inter-organ interactions. In recent years, ever-growing scientific research and innovative advancements in microfabrication technologies have impacted notably on bioengineering and biomedical engineering. One such approach is ‘Microfluidics’ that has emerged as a powerful tool to provide the opportunity to stimulate different organs. The technology of organ-on-a-chip has made it probable to physically and chemically recapitulate the in-vivo conditions by utilising microfluidic approach. Till now, in vitro models of multi-organs including the gut, liver, kidney, lung, heart, and bone have been developed to mimic the organ physiology. Likewise, an integration of multiple organs on a microfluidic platform known as body-on-a-chip model has also been proposed to replicate organ cross talk. This review provides a overview on cell culturing within microfluidics systems, design, fabrication of biochips, organ and body on a chip models, and its applications in the coming future.