Background: Ayurveda is a science of life. It reflects a wonderful amalgamation of the combination of science and philosophy. This holistic knowledge of living is divine which was passed on to the disciples and then to the common man by various oral narrations and writings. Different Samhitas are available as authenticated ayurvedic texts. Charaka Samhita is the most important ancient authoritative writing. Sutrasthana of Charaka samhita comprises the essence of all sthanas. Aims and objectives: To highlight the methodology and specality of Chatuskas of sutrasthana of Charaka Samhita and thus explain the arrangement of Chatuskas. Material and methods: Charaka Samhita and its available commentary were thoroughly studied with special reference to sutrasthana. Conclusion: Chatuska methodology is distinctiveness of the Charaka Saṃhita and was adopted so as to conglomerate the similar descriptions under one heading. It is not only unique presenting way but stands as evidences of the practical approach of Charaka Samhita.