Sepsis is a potentially life threatening complication of an infection. Sepsis occurs chemical released into bloodstream to fight the infection trigger inflammatory response through the body. This inflammation can trigger a cascade of changes that can damage multiple organ system, causing them to fail. Septic shock is defined as sepsis associated with hypotension and perfusion abnormalities despite the provision of adequate fluid resuscitation. Patients with septic shock who are receiving inotropic or vasopressor therapy might still exhibit perfusion abnormalities, despite the lack of hypotension. This was a prospective observational study, which included 75 patients admitted in Pushpagiri Medical College Hospital. The study was done to evaluate the choice of drug in patients with sepsis along with the type of organism and time of treatment, and additional therapy given to the patient. From the present study, it was suggested that the use of antibiotic therapy, especially a broad spectrum antibiotic was the most appropriate initial therapy. Majority of the population uses the broad spectrum antibiotic (Piperacilline-tazobactam), because of the increased anaerobic or aerobic coverage to kill the bacteria.In critically severe patients, a combination of two or more antibiotic is preferred. But there is no difference in overall mortality between monotherapy and combination therapy. The most common causative organism for bacterial sepsis is gram negative organism. In gram negative organism, Echerichia coli,is the most. The time of treatment is very important in the treatment of sepsis. Administration of antibiotics within one hour from admission showed better prognosis when compared with treatment started after one hour, so the time must be taken into consideration for the treatment of sepsis Early goal directed therapy are given inorder to treat hypoxemia, hypotension, hypovolemic conditions of patients. Vasopressors are preferred in certain conditions were IV fluids fails to correct the circulatory dysfunctions.