Gastrointestinal stromal tumors (GISTs) are rare tumors of gastrointestinal tract arising from interstitial cells of Cajal. They present with varied clinical features most of which are non- specific. This study was done to identify the clinical features of GISTS and immunohistochemistry. It was a retrospective and prospective study. The total number of studied patients was 50. Out of 50 patients- 26 were females (52%). Mean Age of involvement was 59 years. Gastrointestinal bleeding and Pain abdomen were the most common symptoms. Stomach was involved in 64%, small gut in28% and colon in 4% of the patients. The average size of the tumor was 5.2cm. 96% were CD117 positive. GISTS are rare tumors arising in late middle age. They affect males and females equally. They present non- specific signs and symptoms. Most of them are CD117 positive.