New developments have been taking place in the field of colon-specific drug delivery scheme in the latest years. Colonic drug delivery has become increasingly important not only for delivering the drug for the therapy of colon-related indigenous illnesses such as Crohn's disease, inflammatory bowel disease, etc. But also to provide protein, therapeutic peptides, anti-asthmatic drugs, medicine and anti-diabetic agents in particular. New colon targeting systems and techniques are created to overcome the constraints of the previous method. Colon targeting has great potential and still wants a lot of creative jobs. This review describes the implementation of colon, wishes, and approaches to the delivery of colonic drugs, the problem of colonic transformation, colonic diseases and thus the new and growing techniques.