In the last few decades, the scientific community has been extensively involved in the investigation about the interaction between infill walls and RC frames in the seismic structural behavior. The infill walls are seldom included in the numerical analysis of reinforced concrete structural Systems since infill panels are generally considered as non-structural components. However, these panels affect the structural response to a large extent, because the complexity they introduce to analysis, kept them unaccounted. Therefore, it is crucial to understand the contribution of infill walls to earthquake response of the Structures. In this study, an attempt is made to do comparative analysis and design of the structure when the structure is modeled using different types of infill walls. In this study, an R/C frame structure with a different type of infill walls like AAC Block, Clay Brick, are considered to investigate the effect of different types of infill walls on earthquake response of the structures. The RCC frame analyzed & designed by using STAAD-Pro software. The diagonal strut approach is adopted for modeling of infill walls. The analytical results of the building frame will be compared and analyzed to obtain are storey drift, base shear, Lateral displacement, shear force and bending moment when subjected to static earthquake loadings.