Padadari is one of the commonest and most neglected diseases. Most of the people work in farms in wet soil or water without protecting the feet. Some people don’t use foot wears and walk bare foot. Such reason leads to incidence of cracking the skin of the feet, which is very common. The present study objectives are to evaluate the efficacy of Madanadi Lepa with and without Siravyadha in Padadari. In this trial, total 40 cases were studied into two groups as ‘A’ and ‘B’ each group consisting of 20 patients, Group A patients was advised Madanadi Lepa and Group B Siravyadha with Madanadi Lepa. The present study reveals that in Group A, none had complete relief, 2 patients (10%) had marked improvement and 11 patients (55%) had Moderate improvement, 7 patients (35%) had mild improvement.In Group B, none had complete relief, 3 patients (15%) had marked improvement, 13 patients (65%) had Moderate improvement and 4 patients (20%) had mild improvement After the total course of intervention, the data obtained towards the results indicate that Group B showed good response on symptoms than Group A after treatment and at the end of follow up. It was an attempt made to clinically compare the effect of Sagritha Yavakshara Lepa and Katutaila abhyanga in Padadari.