Quantification is a major step in the pharmaceutical industry for determining the quantity and quality of a specific Active Pharmaceutical Ingredient in each drug formulation. This step is a major step for commercializing and marketing the drug. Several methods have been developed for the quantification of the drug but the most used are UV and HPLC methods. In this study, we try to review the various quantification methods by UV and HPLC and accomplish that which method is better for the Quantification of Gastroretentive drugs. Gastroretentive drug delivery system is a type of drug which retains for a prolonged time in the Gastrointestinal tract and does not get disintegrated immediately. One type of Gastroretentive drug is Gastroresistant drugs which do not disintegrate regardless of the acidic pH of the stomach but gets absorbed in the surface of the intestines at a basic pH. This is possible because these types of drugs are enteric-coated. Spectrophotometry techniques can be used as an alternative method for HPLC for the quantification of Gastroretentive drugs.