This paper deals with the Comparative Study of the composite and concrete structure. The composite structure is more prominent over steel and concrete structure in relation to Strength, Costs, and Time Period requirements. There is no need for formwork because the steel beam is able to sustain its self-weight of steel and concrete, by itself or with the assistance of a few temporary props. This Paper also deals with the design of composite building structures with a fixed base. In this paper Seismic analysis of a multi-story residential building is made by using different construction materials like Concrete, Structural Steel and Composite of Structural Steel and Concrete. Effect of the building is studied with respect to base shear, total dead load, story drift values in both X- and Y- direction. Steel-concrete composite systems for buildings are built by connecting the steel beam to the concrete slab or profiled deck slab with the help of mechanical shear connectors so they seem like a single unit and act accordingly. In the present work, the steel-concrete composite with RCC options is chosen for the comparative study of G+21 story building which is situated in earthquake zone-III and for earthquake loading, the provisions of IS: 1893 (Part1)-2002 is considered. Here, we used ETAB Software for three-dimensional modeling and the analysis of the structure.