The effect of infill walls on the building is generally neglected in the analysis. In fact, an infill wall contributes to the lateral strength and stiffness of the structure. Seismic response analysis of multi-story building frame with infill was done by modeling the infill wall as an equivalent diagonal strut. For the equivalent diagonal strut, the thickness is taken equal to the thickness of the wall and width of the strut as per “Equivalent strut method”. The comparison of seismic responses is done for the multi-storied buildings with infill as an equivalent diagonal strut using linear and non-linear analysis. ETABS software is used for the present study.