Eye-hand coordination abilities are an integral part of a Child’s development. Eye-hand coordination is necessary for functional independence progress and its effects on the activity of daily living. This study is aimed at the effectiveness of coordination exercise on activity of daily living and the correlation between coordination exercise and activity of daily living. Total 20 children (7 Female, 13 Male) age group 10 to 15 years with different disabilities situated around Anand. Developmental Coordination Questionnaires (DCDQ) was used for assessment of coordination skill. Functional Independence Measure (FIM) was used for evaluating the activities of daily living. The coordination exercise program was effective for an activity of daily living in differently able children. Coordination exercise was positively associated with Activity of daily living. Coordination has an effect on Activity of daily living. After the coordination exercise program, the child improved his/her Coordination skill. Coordination exercises are effective on an activity of daily living in differently able children.