ABSTRACT: Background: Cardiac arrest is leading cause of death in India and globally. cardiac arrest death is no one in non-communicable death in India. According to American heart Association general Worldwide, there are >135 million cardiovascular deaths each year. In India, it is estimated that about 5-6 lakh people die every year due to sudden cardiac arrest, and a good proportion of them are under the age of 50. Prompt response by health care professional and provide High quality CPR combination of Chest Compression at the rate of 100-120 compression/min, with depth of compression 5-6 cm without any interruption, complete chest recoil and give 2 rescue breathing within 10 seconds after opening airway by head tilt and chin lift for medical victim and jaw thrust for trauma victim, which is delivered continued cycle during cardiac arrest by one or 2 rescuer in out hospital and through megapode team in hospital Continue CAB 5 cycle of High-quality CPR within 2 minutes. Methods: Its Cross-Sectional study of duration of 2 month from November 2023 to December 2023.continued among health care professional working at Goyal Hospital and Research centre pvt ltd. Knowledge assessed through 20 multiple questions and practiced assessed by skill check list contain 10 points of High-Quality CPR and attitude observed and assessed by verbal question while skill case scenario. Result: The median for knowledge score nursing staff was 14.5 (70.25%) and Practice score median was 7 (70%). knowledge score between critical and nun critical area was not found statistically significant. Distribution of subjects based on scores in knowledge and of High Quality BLS 5.55% (5) of Nursing staff poor knowledge score and 30% (27) of nursing staff had average knowledge score. 55.55% (50) having good knowledge score .and remaining 8.88 (8) are excellent in knowledge Conclusion: The present study identified the Knowledge and practice score of BLS or CPR is Average in nursing staffs, even though they have positive and good attitude towards it. BLS training should be the part of the curriculum and CNE to solve this issue.