The present study is on to regulate the nutritional supplements for labeling and advertising. Nutritional are commonly used in the entire world. There is a tendency for underreporting their ingestion by patients and the magnitude of their use is under-recognized by Physicians. This review will mainly discuss single ingredients and complex mixtures of natural nutrition’s marketed under a single label and advertising. These create difficulties in developing and harmonizing nutrition information listings, which have broad international applications. For these reasons, the Codex guidelines on nutrition labeling play an important role to provide guidance to member countries when they want to develop or update their national regulations and to encourage harmonization of national standards with international standards. As for all products on the market, advertising for dietary supplements must be truthful and substantiated. The U.S Food and Drug Administration (FDA) and Federal Trade Commission (FTC) work together in regulating dietary supplement advertising. FDA is primarily responsible for claims on product labeling, while FTC has primary responsibility for claims in advertising, including print and broadcast ads, infomercials, catalogs, and similar direct marketing materials. These two agencies collaborate to ensure consistency in dietary supplement advertising regulation. The conclusion of current regulations for labeling and advertising of nutritional supplements was marketers of dietary supplements should be familiar with the requirements under both DSHEA and the FTC Act that labeling and advertising claims be truthful, not misleading and substantiated.