Globally every country is the victim of misbranded or adulterated drugs, which result in life threatening issues, financial loss of consumer and manufacturer and loss in trust on health system. For minimizing adulterated and misbranding drugs or not of standard quality drugs, there is urgent requirement of more stringent regulation and legal action against the problem. The adulteration and substitution of crude drug is a burning problem. substitution is helpful in places where unavailability of particular crude drug and or unwanted adverse effects of desired crude drug are there and have a choice of other drug with similar pharmacological effect and less unwanted after effects. But in most cases, it is unacceptable because the conversion of authentic drug into substandard drug may cause variety of adverse effects from mild and moderate to severe life threatening reactions. So, understanding of all the ways of adulteration and substitution is necessary to rectify this illegal act and maximizing consumers' safety. However, India has taken some preventive steps in the country to fight against the poor quality of regulatory organization drugs for protecting and promoting the public health.