The paper analyses the Disease impact on patients as well as their parents, with congenital heart diseases. The aim of the study is to analyze the perspective of adolescents and their parents on perception about the disease. The study was initiated to compare the attitude of parents and children (age 13-18 years), who can lead a normal life after corrective surgery/treatment. Methods: The data was collected from two reputed hospitals of Delhi, having pediatric cardiology department running for almost more than 10 years. A Questionnaire from PCQLI was used to collect data, with their permission. The questionnaire is already valid and reliable. A study was conducted, with permission from hospital authorities. A sample of around 30 patients (Parents /Children) were collected to study the quality of life aspect using various Disease impact parameters. An independent sample t-test was applied to compare the perspective of two groups. Findings: The result was analyzed between the perspective difference between parents and children population on the Disease impact aspect. The data showed some variables reflect a significant difference between parents and children but some variables do not reflect any difference. Recommendation: The findings from the study indicate a need to peep into Disease impact aspect and would help the treatment provider to better treatment methods of patients with congenital heart disease so that they can be helped to better manage their health perspective in future.