The advent of digitalization has taken India by storm and the pharma sector is also not left behind. The trend of purchasing medicine online is increasing and so is the number of e-pharmacy start-ups. E- Pharmacies are recent entrants in the Indian e-commerce industry and receiving attention from the government as well as global investors from the past three years. The Ministry of Health and Family Welfare, Government of India has published draft rules on 28th August 2018, with the heading “Sale of drugs by e-pharmacy” to bring e-pharmacies within the scope of Drug and Cosmetics Rules, 1945 by making amendments in it which currently does not distinguish between online and brick and mortar pharmacies. It aims to regulate online sale of quality medicines pan India through e-pharmacies registered under Central Drugs Standard Control Organisation (CDSCO), India’s apex drug regulator and central licensing authority, where all records are maintained as per rules laid down. The confidentiality of patient details have to be maintained and cannot be disclosed to anyone one under any circumstances other than the central or state government as the case may be. The sale of tranquilizers, narcotic and psychotropic substances and Schedule X drugs are not permitted through e- pharmacies. The dawn of 2019 is expected to bring a brighter future for a fully legitimate and professionally managed E- Pharmacies in India.