Using corrugated channels is one of the passive heat transfer enhancement techniques in the fabrication of heat exchange devices. Designing more effective energy systems is a challenge for researchers and engineers to minimize the consumption of energy in order to improve energy system efficiency. In the present research, an experimental study of forced convective flows of different nanofluids through a trapezoidal corrugated channel at a constant wall temperature condition was performed. Numerical simulation of a corrugated channel was applied by using the nanofluid to probe the characteristics of the flow and thermal fields. For the purpose of solving the governing equations with corresponding boundary conditions, the finite volume method is employed by implementing the CFD commercial software ANSYS-FLUENT-V16. The channel was tested under a constant heat flux of 10 KW and the volume fraction of nanofluid is taken as 0.08. it was found that the pressure drop is found highest in the nanofluid tio2-water and is decreasing in the sequence is TiO2> SiO2>Fe2O3> Al2O3> ZnO> CuO.