The present study was conducted to assess the effect of honey mixture therapy on obesity among adolescent girls. Objectives: Assess the degree of obesity among adolescent girls, Assess the effectiveness of honey mixture therapy on obesity among adolescent girls, Find the association between obesity and selected demographic variables of adolescent girls. Methodology: Quantitative approach was used for the study and a pre-experimental one-group pre-test post-test design was selected. This study was based on the Penders health promotion model. Data were collected from 30 obese adolescent girls residing in selected hostels at Perinthalmanna using a nonprobability purposive sampling technique. Semistructured interview schedules on sociodemographic data and physiological methods were used to obtain baseline pre-test measurements. Honey mixture therapy was administered for 45 days and post-test measurements were also collected. The data were analyzed and interpreted by using descriptive and inferential statistics. Results; the mean post-BMI score (27.79) is less than the mean pretest score(28.20). The obtained t value is 0.85 and the p-value is 0.40. The mean difference is not statistically significant. The study also revealed that there is a significant association of obesity with the availability of pocket money. Conclusion; the study concluded that there is a nonsignificant reduction in BMI followed by administration of honey mixture therapy for a period of 45 days.