The main aim of this study was to investigate the effect of Naringenin, a flavonoid on 3-Nitropropionic acid (3-NP)-induced Huntington’s disease like symptoms by estimations of motor co-ordination and behavioral parameters. 3-NP is an irreversible inhibitor of complex II in the mitochondria. 3-NP-induced neurodegeneration has been widely used as an animal model of Huntington’s disease (HD). It replicates the pathology of HD by causing oxidative stress. Naringenin is a polyphenolic compound, a bioflavonoid, known to have a neuroprotective effect in a rat model of Alzheimer’s disease. In the present study, the neuroprotective effect of Naringenin on 3-NP induced oxidative stress in rat was determined by behavioral parameters. Rats were induced with 3-NP (15 mg/kg) intraperitoneally for 21 days and rats induced with 3-NP were treated with Naringenin (25mg/kg and 75mg/kg) for 21 days. 3-NP caused a decline in motor function in neurological score, locomotor activity and impaired rotarod activity. Naringenin treatment significantly improved grip strength indicating an improvement in motor performance, alterations in % spontaneous alternations. These findings suggest the antioxidant potential of Naringenin flavonoid against 3-Nitropionic acid induced neurotoxicity. However, more investigations are required to elucidate the cellular mechanisms of Naringenin against 3-Nitropropionic acid induced Huntington’s disease like symptoms. Keywords: Naringenin, 3-Nitropropionic acid, Huntington’s disease, oxidative stress.