The present study entitled “Effect of Structured Teaching Program on Knowledge regarding Cardiopulmonary Resuscitation among Degree students” is based on following Objectives: Assess the pre-test and post-test level of knowledge regarding Cardiopulmonary Resuscitation among degree students; Evaluate the effect of Structured Teaching Program on Knowledge regarding Cardiopulmonary Resuscitation among degree students; Find out the association between the pre-test level of knowledge and selected demographic variables. Methodology: The quantitative approach was used for the study and Pre experimental one group Pre-test Post-test design was selected. This study was based on J W Kenny’s Open System theory. The present study was conducted at MES KVM College, Valancherry among 100-degree students. The samples were selected by using a nonprobability convenient sampling technique. Data were collected by using structured knowledge questionnaire to assess the knowledge regarding CPR. Structured Teaching Program was given on the same day and after 7th day the post-test was done, Analysis: Data were analyzed by using descriptive and inferential statistics. Results: The mean post-test knowledge score 21.57 was significantly higher than pre-test knowledge score 12.56. The obtained t value was 27.445 and the p-value was 0.0001. The findings showed that the Structured Teaching Program on CPR was effective. There was a significant association between the pre-test knowledge score with their course of study. The study concluded that a structured teaching program was effective in improving the knowledge of degree students.